3. Markedly Swollen Joints

The inflammatory process of the body also releases nerve-stimulating chemicals into the blood stream that make their way toward the affected joint. These chemicals, such as bradykinin and histamine, serve to protect tissues from further damage but may also cause some pain when they come into contact with nerve endings. This is the reason why patients with gout experience a sharp, excruciating pain even at the slightest touch of the affected joint.