5. Cleveland, Ohio

With a poverty rate double than that of the national average, Cleveland ranks as one of the poorest in the country, having 35% of its 386,000 residents struggling under the poverty line. With this widespread poverty, crime rates have also skyrocketed, prompting job-producing businesses either closing or seeking to set up shop elsewhere. Business are not the only ones leaving the city as more and more residents prefer to live elsewhere in search of a better quality of life.